WebPopular answers (1) 8th May, 2012. Marije I Koenders. Radboud University. Depending on the aspect of your research, you might consider fibroblasts (3T3-NIH), macrophages … WebSynovial fibroblasts of rheumatoid arthritis (RA) play a critical role in perpetuation of chronic inflammation by interaction with immune and inflammatory cells and in cartilage and bone invasion, but current therapies for RA are not directly targeted fibroblasts. Selectively fibroblast targeted therapy has been hampered because of lack of fibroblast specific …

Modeling Rheumatoid Arthritis In Vitro: From Experimental

WebOct 23, 2024 · Rheumatoid arthritis (RA) is a multifactorial autoimmune disease of unknown etiology, primarily affecting the joints, then extra-articular manifestations can … To identify key driver TFs in rheumatoid arthritis we have applied Taiji to integrate genomic information from individual RA FLS lines into transcriptional regulatory networks. TFs were then ranked on their regulatory influence and cell lines clustered according to driver TF profiles. Computational assessment of the … See more We constructed genetic networks in FLS from RA patients using the Taiji pipeline (Fig. 1a, “Methods” and Supplementary Fig. 2). Taiji first … See more A unique feature of Taiji is that it can be applied to individual primary cell lines derived from RA patients. We built the genetic network in each RA cell line, based on which the PageRank score for each TF in each cell … See more SMAD-independent TGFβ signaling mechanisms can also initiate non-canonical effects, including activation of the cell cycle. In light of the known non-canonical TGFβ … See more Using the network topologies predicted by Taiji, the ratio of gene expression between all pairs of topologies (response) was predicted based on the ratio of expression levels of their specific … See more food in gulf shores

Understanding rheumatoid arthritis at the cellular level

WebNov 28, 2007 · Introduction. Methotrexate (MTX), the most frequently used disease-modifying anti-rheumatic drug (DMARD), suppresses disease activity and reduces joint damage [].The precise mechanism of action of folate antagonist MTX in the treatment of rheumatoid arthritis (RA) is unclear, although it is thought that MTX prevents de novo … WebResearchers identified ways that immune cells and joint cells interact to produce the inflammation and tissue damage seen in rheumatoid arthritis. Understanding these … WebFeb 15, 2024 · In cancers and other complex diseases, the fusion of two genes can lead to the production of chimeric RNAs, which are associated with disease development. Several recurrent chimeric RNAs are expressed in different cancers and are thus used for clinical cancer diagnosis. Rheumatoid arthritis (RA) is an immune-mediated joint disorder … fooding works ログイン画面