Cisplatin and sodium thiosulfate
WebAug 2, 2024 · A randomized controlled trial to test the efficacy of trans-tympanic injections of a sodium thiosulfate gel to prevent cisplatin-induced ototoxicity in patients with head … WebSep 21, 2024 · About PEDMARK® (sodium thiosulfate injection) PEDMARK ® is the first and only U.S. Food and Drug Administration (FDA) approved therapy indicated to reduce …
Cisplatin and sodium thiosulfate
Did you know?
WebMar 29, 2024 · An important step forward in addressing this was the recent approval of intravenous sodium thiosulfate by the US Food and Drug Administration to treat ototoxicity in pediatric patients with localized, nonmetastatic solid tumors. 11 However, for adult patients, there are no currently approved therapies for cisplatin-induced ototoxicity. Until ... WebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been fully elucidated.
WebFeb 17, 2024 · Cisplatin extravasation, concentrated: Infants, Children, and Adolescents: Inject 2 mL of a 1/6 M (~4%) sodium thiosulfate solution into existing IV line for each 100 mg of cisplatin extravasated; consider also injecting 1 mL of a 1/6 M (~4%) sodium thiosulfate solution as 0.1 mL subcutaneous injections (clockwise) into the area around … WebApr 7, 2024 · The active substance of Pedmarqsi is sodium thiosulfate (ATC code not yet assigned), an antidote with a mechanism of action that is not fully understood but is thought to include increasing levels of endogenous antioxidants, inhibition of intracellular oxidative stress and direct interaction with cisplatin to prevent cisplatin-induced damage to …
WebApr 7, 2024 · On 30 March 2024, the European Medicines Agency’s (EMA’s) Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending … WebApr 9, 2024 · In the COG ACCL0431, the hearing loss incidence rate was 28.6% in patients treated with sodium thiosulfate plus cisplatin compared with 56.4% in the cisplatin …
WebApr 14, 2024 · Clinically, sodium thiosulfate (STS) is an approved drug for the treatment of acute cyanide and cisplatin toxicity. IR protective abilities of STS are reported with in-vivo models of myocardial IR as both preconditioning and post conditioning agent (Ravindran and Kurian 2024a ).
WebOct 6, 2024 · Sodium thiosulfate prevents hearing loss and is safe. Cisplatin belongs to a group of platinum-based chemotherapy drugs. Research has suggested that hearing … citya lyon vendomeWebDec 30, 2024 · I. Evaluate disease recurrence patterns: locoregional versus distant. OUTLINE: Patients undergo cytoreduction. Patients also undergo HIPEC over 60 minutes consisting of doxorubicin and cisplatin. Patients then receive sodium thiosulfate intravenously (IV) over 12 hours. dickson mounds lewistown ilWebApr 25, 2024 · Drug: Cisplatin Drug: Sodium thiosulfate Procedure: Cytoreductive surgery: Phase 2: Detailed Description: Adrenocortical carcinoma (ACC) is a rare tumor with an overall 5-year mortality rate of 75 - 90% and an average survival from the time of diagnosis of 14.5 months. The treatment of choice for a localized primary or recurrent … city amaWebDosing per FDA Guidelines. The recommended dose of sodium thiosulfate (e.g., Pedmark) is based on body surface area according to actual body weight as summarized below … citya macon locationWebFeb 1, 2024 · Sodium thiosulfate is also used to reduce the risk of hearing loss in children 1 month of age and older who are receiving medicines (eg, cisplatin) for cancer that have not spread throughout the body. This medicine is to be given only by or under the immediate supervision of your doctor. This product is available in the following dosage forms: city alvin texasWebMany cisplatin-protective agents have been evaluated: sodium thiosulfate , glutathione (GSH) , GSH ester , vitamin C , and sodium salicylate . However, to date, there are no methods that can completely prevent the loss of hair cells or the dysfunction of auditory nerves in cases of cisplatin-induced ototoxicity. dickson murehwaWebCisplatin-induced ototoxicity is caused by irreversible damage to hair cells in the cochlea hypothesized to be due to a combination of reactive oxygen species production and direct alkylation of DNA leading to cell death. Sodium thiosulfate interacts directly with cisplatin to produce an inactive platinum species. Regulatory Status city aluminum foundry waterford mi