Cyp46a1 protein
WebNov 16, 2024 · The crystal structure of human CYP46A1 P450 with ligand cholesterol-3-sulphate bound (PDB: 2Q9F; X-ray diffraction 1.9 Å) and unliganded structure of the … WebCYP46A1 belongs to cytochrome P450 family of enzymes and it localize to ER/microsomes as single-pass membrane protein, and unlike other cytochrome P450 sterol hydroxylases that are predominantly expressed …
Cyp46a1 protein
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WebCYP46A1. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC. Assigned HPA protein class (es) for the encoded ... WebJan 1, 2024 · Consistent with HMGCR, CYP46A1 protein level was up-regulated in response to Aβ treatment. Based on our findings, we can suggest that increased expression of CYP46A1 level can be a regulatory positive feedback to keep neurons active in order to inhibit cholesterol accumulation in case of increased levels of HMGCR protein and …
WebSep 22, 2024 · CYP46A1. cytochrome P450 family 46 subfamily A member 1. Gene ID: 10858, updated on 22-Sep-2024. Gene type: protein coding. Also known as: CP46; … WebMar 22, 2024 · When Cyp46A1 was overexpressed in NIH3T3 cells, intrinsic oxysterols increased in the order 24S-HC > 25-HC > 27-HC. We investigated the mechanism regulating the production of endogenous oxysterols in NIH3T3 cells by Cyp46A1 and found that the mRNA, relative protein levels and enzymatic activity of Cyp46A1, and the amounts of …
WebPROTEIN SUMMARY SECTION OVERVIEW RNA DATA. CYP46A1 INFORMATION. Proteini. Full gene name according to HGNC. Cytochrome P450 family 46 subfamily A … WebMar 2, 2024 · This aberrant oligomerization of ATAD3A induced AD-like hyperconnectivity of MAMs and impaired neuronal cholesterol turnover by inhibiting CYP46A1 (Cytochrome P450 Family 46 Subfamily A Member 1)...
WebCYP46A1 protein levels were decreased in the putamen, but not cerebral cortex samples, of post-mortem Huntington's disease patients when compared to …
WebJan 29, 2016 · CYP46A1 protein levels were decreased in the putamen, but not cerebral cortex samples, of post-mortem Huntington’s disease patients when compared to controls. Cyp46A1 mRNA and CYP46A1 protein levels were also decreased in the striatum of the R6/2 Huntington’s disease mouse model and in ST hdh Q111 cell lines. thalway inflatable ring seat cushionWebMar 21, 2024 · CYP46A1 (Cytochrome P450 Family 46 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP46A1 include Alzheimer Disease, Familial, 1 and Cerebrotendinous Xanthomatosis . Among its related pathways are Oxidation by … FASN (Fatty Acid Synthase) is a Protein Coding gene. Diseases associated with … CYP1A2 (Cytochrome P450 Family 1 Subfamily A Member 2) is a Protein … ACE (Angiotensin I Converting Enzyme) is a Protein Coding gene. Diseases … SLC7A5 (Solute Carrier Family 7 Member 5) is a Protein Coding gene. Diseases … NOX4 (NADPH Oxidase 4) is a Protein Coding gene. Diseases associated with … FDFT1 (Farnesyl-Diphosphate Farnesyltransferase 1) is a Protein … CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) is a Protein … ACHE (Acetylcholinesterase (Cartwright Blood Group)) is a Protein Coding gene. … PLAU (Plasminogen Activator, Urokinase) is a Protein Coding gene. Diseases … synthes xrlWebCYP46A1 Protein Overview Lund et al. (1999) used expression cloning to isolate cDNAs that encode murine and human cholesterol 24-hydroxylases. DNA sequence analysis indicated that both proteins are localized to the endoplasmic reticulum, share 95% identity, and represent a new cytochrome P450 subfamily (CYP46). synthesys softwareWebCat.No. : CYP46A1-03H Optional Service: Optional requirements on this protein Product Overview : Recombinant human CYP46A1 and human CYP-reductase without tag was coexpressed in Escherichia coli. synthes x platteWebJul 16, 2013 · The CYP46A1 protein in the brain was located to neuronal cells. It is evident that there are very specific requirements for expression of this protein in different cells. Under normal conditions CYP46A1 protein is almost exclusively expressed in neuronal cells in the brain and in the eye. It seems likely that there a number of restrictions ... thalweg definition geographyWeb当你希望让更多商家联系你时，可以勾选后发送询价，平台会将你的询价消息推荐给更多商家。 synthesys researchWebCYP46A1. METABOLIC PATHWAYS. Human metabolism. GENERAL INFORMATIONi. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. synthes wrist plate