Olfm4 and cancer

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August undefined, 2024

Web02. maj 2024. · OLFM4 promotes tumor cell proliferation by activating STAT3 and accelerating cell-cycle progression in gastric cancer 22 and pancreatic cancer. 25 … Web27. feb 2024. · A Data Scientist with pre-Sales Experience. Proven success in delivering transformational, never done before AI wins across the region, in both a startup and a large complex organization. A developer at heart but with an eye for practical AI and creating impact with technology. I’m a co-author of multiple Cancer publications and hold a MSc …

OLFM4 deficiency delays the progression of colitis to colorectal …

WebNational Center for Biotechnology Information WebOlfactomedins (OLFMs) are a family of glycoproteins that play a relevant role in embryonic development and in some pathological processes. Although OLFM2 is involved in the regulation of the energy metabolism and OLFM4 is an important player in inflammation, innate immunity and cancer, the role of OLFMs in NAFLD-related intestinal dysbiosis … spherical radial and bilateral symmetry

OLFM4 deficiency delays the progression of colitis to colorectal …

Web10. apr 2024. · Gastric cancer is a dominant source of cancer-related death around the globe and a serious threat to human health. However, there are very few practical diagnostic approaches and biomarkers for the treatment of this complex disease. ... SFRP4, CDH17, FAP, CLDN1, and OLFM4 were of the highest LogFC values among the upregulated … WebAs a target gene of important signal pathways implicated in cancer and inflammation, OLFM4 may emerge as a potential therapeutic target for these diseases. Recent publications have also reported increased expression of OLFM4 in gastrointestinal cancer ( 10 – 13 ) and inflammatory disease including inflammatory bowel disease ( 14 ) and H ... WebOLFM4 expression has been studied in several tumor types including gastric, colorectal, lung, and endometrioid cancers where it has been suggested to be an independent … spherical random antenna array

Loss of OLFM4 promotes tumor migration through …

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Web28. sep 2010. · The OLFM4 gene was first identified by virtue of its high expression in colon cancer cells through analysis of Cancer Genome Anatomy Project data from the United States National Cancer Institute. The gene was originally cloned from human haematopoietic myeloid cells and mapped to chromosome 13q14.3 [].It consists of five … spherical radarWeb03. apr 2012. · Human olfactomedin 4 (OLFM4) gene is a secreted glycoprotein more commonly known as the anti-apoptotic molecule GW112. OLFM4 is found to be frequently up-regulated in many types of human tumors including gastric cancer and it was believed to play significant role in the progression of gastric cancer. Although the function of OLFM4 … spherical range image

"Web27. maj 2024. · OLFM4 is highly expressed in polymorphonuclear bone marrow-derived inhibitory cells in colitis and colorectal cancer, its expression levels and cell populations are positively correlated with the ... " - Olfm4 and cancer

Olfm4 and cancer

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WebOLFM4 is proved to as a functional target for miR-590. PMID: 28012926; Olfactomedin 4 is a novel tumor marker for triple-negative breast cancer for predicting and prognosis. PMID: 27939521; OLFM4 is downregulated by miR-486-5p, which contributes to … Web09. feb 2024. · INTRODUCTION. Pancreatic ductal adenocarcinoma (PDAC) has recently surpassed breast cancer to become the third leading cause of cancer-related mortality according to the American Cancer Society, with a 5-year survival in the single digits [].Despite improvements in surgical techniques and adjuvant chemoradiotherapy, the …

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Web25. avg 2024. · Given the presence of BChE + cells in the crypts and the fact that crypts contain functional stem cells scattered amongst Paneth cells, double-label experiments were also performed to test the expression of olfactomedin-4 (Olfm4), which has recently emerged as a robust marker of murine intestinal stem cells (Schuijers et al., 2014). Web13. maj 2016. · OLFM4 expression is correlated with cancer differentiation, stage, metastasis, and prognosis in a variety of cancers, suggesting its potential clinical value …

Web01. mar 2007. · The results indicate that OLFM4 promotes proliferation of PANC‐1 cells by favoring transition from the S to G2/M phase and inhibition of small interfering RNA did not promote apoptosis. Induction of olfactomedin 4 (OLFM4GW112/hGC‐1) in cancer cells was recently reported to have a novel antiapoptotic action via binding to the potent apoptosis … Web18. jul 2024. · Cancer molecular subtyping (describing cancer subtypes) is important not least because of its potential relevance to choice of treatment [1,2].In the case of Colon Cancer, classifications of colorectal cancers (CRC) can be subdivided into 3–6 subtypes, based on gene expression profiles [1,2,3,4].Alternatively, CRC has been shown to divide …

Web15. mar 2024. · Low expression of OLFM4 promoted lymph node and distant metastasis resulting in a poor prognosis of triple-negative breast cancer patients and low expression of OLFM4 in early gastric cancer was ... Web10. jan 2007. · Overexpression of the olfactomedin 4 (OLFM4 GW112,/hGC−1) gene was recently reported to inhibit various apoptotic pathways and promote proliferation of …

Web01. jun 2016. · Development of colorectal cancer (CRC) is regulated by a series of genetic and microenvironmental alterations. Olfactomedin 4 (OLFM4) is a secreted glycoprotein …

Web02. maj 2024. · Conclusion: OLFM4 is induced by the LGR5-Wnt signaling pathway and is strongly associated with aggressive tumor progression and poor prognosis in HCC by regulating STAT3-induced tumor cell proliferation and cancer stem cell–like property. Therefore, OLFM4 is a novel prognostic predictor and a potential therapeutic target for … spherical radius formulaWeb21. mar 2024. · OLFM4 (Olfactomedin 4) is a Protein Coding gene. Diseases associated with OLFM4 include Atrophy Of Prostate and Colonic Benign Neoplasm.Among its … spherical rangeWebChronic inflammatory bowel disease (IBD) is strongly associated with the development of colitis-associated tumorigenesis (CAT). Despite recent advances in the understanding of … spherical reflectionWebNational Center for Biotechnology Information spherical rectangleWeb目的研究P27kipl和CyclinA蛋白在胃癌中的表达,探讨其在胃癌发生、发展中的可能作用及意义。方法应用免疫组化S-P法检测P27kipl和CyclinA蛋白表达情况。结果 P27kipl和CyclinA蛋白在62例胃癌中表达阳性率分别为27.4％和41.9％;58例癌前病变中分别为44.8％和22.4％;25例正常对照组中分别为84.0％和0.0％,胃癌与癌前 ... spherical reflectorWeb29. mar 2024. · circulating OLFM4 could be an interesting biomarker of early breast cancer. high expression of OLFM4 was involved in chemoresistance and was an independent … spherical refractionWeb21. mar 2024. · OLFM4 (Olfactomedin 4) is a Protein Coding gene. Diseases associated with OLFM4 include Atrophy Of Prostate and Colonic Benign Neoplasm.Among its related pathways are Innate Immune System and Adhesion.Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and cadherin binding.An … spherical refracting surface formula