WebIn a systematic review and meta-analysis of randomized controlled trials, the authors concluded that intrathecal administration of dexmedetomidine prolongs postoperative analgesia duration, decreases 24-hr pain intensity, and decreases the incidence of shivering without an increase in other adverse events. 31 Intrathecal dexmedetomidine increases … Web14 Apr 2024 · Time to stop class III or IV shivering on the Crossley and Mahajan standardized shivering scale after the administration of the study drug (meperidine versus dexmedetomidine) Secondary Outcome Measures : incidence of adverse effects [ Time Frame: 24 hours ] sedation, nausea, vomiting, hypotension and bradycardia
Preventing shivering with adjuvant low dose intrathecal …
Web28 Mar 2014 · It has been used mainly as an analgesic drug for nociceptive pain, as well as a treatment for the prevention of postoperative shivering and hiccups. Based on NFP's mechanisms of analgesic action, it is more suitable for the treatment of neuropathic pain. ... has been compared with various drugs, such as meperidine, tramadol, clonidine, and ... WebDexmedetomidine (DEX) is a highly selective α-2 receptor agonist used to reduce the shivering threshold and has proven to have a better anti-shivering effect than meperidine. 9–11 A meta-analysis by Hoffman et al. 12 revealed that intravenous (IV) DEX was not an optimal choice against PAS because of cardiovascular adverse effects. segway topic
Comparative Randomized Controlled Blind Study of the Anti-Shivering …
WebPostoperative shivering (POS) is anearly complication following craniotomy. Preventive pharmacologic drugs are the mainstay of treatment. Meperidine is the drug of choice but with increased risk of apnea. Objectives To assess the preventive effect of Ondansetron on POS after craniotomy. Methods Web1 Feb 2024 · Meperidine’s anti-shivering effects have been attributed to its actions on the κ-opioid receptor [ 6] and the α 2b adrenoreceptor subtype [ 7 ]. Side effects associated with meperidine administration include nausea, vomiting, and pruritus [ 8 ], as well as respiratory depression at higher doses [ 9 ]. Web3 Feb 2024 · Shivering is a common complication in the postoperative period. The incidence of shivering has been reported to range from 5% to 65% under general anesthesia and as 33% during epidural anesthesia. Shivering can increase perioperative risk in patients. segway superscooter